The Role of Objective Lenses in the Department of Pathology

May 05, 2025 Leave a message

A Zeiss Primo Star microscope is always on the workbench of Professor Li Mingyuan, head of the Department of Pathology at Peking Union Medical College Hospital. The metal housings of the four objective lenses on this instrument's objective converter are worn to a shine, especially the 40x objective lens, which is covered with fine scratches.' These marks,' Professor Li said, 'are all witnesses to the speed of life and death.'

 

When Professor Li first joined the Department of Pathology in 1987, he used a monocular microscope with a numerical objective aperture of only 0.65. At that time, breast cancer diagnosis relied mainly on hematoxylin-eosin staining, and many tiny nests of cancerous cells were easily missed under the low-resolution objective. He remembers a 32-year-old female teacher who had been treated for 'breast hyperplasia' for two years at an outside hospital until she came to Concordia for consultation, where early invasive carcinoma was detected under a high-resolution objective lens.' If there had been a better objective lens, it could have been detected earlier.' Professor Li's tone was tinged with regret. 2003 during SARS, the Department of Pathology witnessed a leap in objective lens technology. The application of fluorescence objectives made the identification of viral inclusion bodies possible.

 

Professor Li recalled, 'At that time, we wore level 3 protective clothing and double gloves to operate the microscope, sweat blurred the eyepieces, but the features of the virus under the fluorescence objective were exceptionally clear.' It was these observations that provided the key basis for clinical diagnosis. Professor Chen Zhiqiang of the Department of Pathology at Guangzhou Zhongshan Hospital, on the other hand, has experienced the transition from optical microscopy to digital pathology.' Previously we relied on objective lens observation, but now we rely on digital slice scanners,' he said, 'but the choice of objective lens is still critical.' He showed off his latest acquisition, a flat-field compound achromatic objective, which has a 95 per cent flatness of the image field at the edges, allowing for a dramatic increase in the accuracy of teleconsultations.

 

The stories of several pathologists reflect the evolution of objective lens technology in medical diagnosis. From ordinary bright field to fluorescence, phase contrast, and then to digital imaging, every innovation in objective lens technology means improved diagnostic accuracy and more lives saved in time. In addition, our company also sells all kinds of objective lenses, such as 40x objective lens, 100x objective lens, eyepiece and objective lens and so on, welcome to buy.